7-Aminoclonazepam, Confirmation
CPT Code(s):
80346
Turnaround Time:
24 - 72 hours
Specimen Requirements
Preferred Specimen:
Urine
Minimum Volume:
5.0 mL
Transport Container:
Yellow Top Tube or Sterile Cup
Transport Temperature:
Room Temperature
Collection Instructions:
Collect urine in plastic container and transfer to plain yellow top tube (without preservative).
Rejection Criteria:
Specimen received outside stability requirements; Excessive blood, particulates, viscosity present. Preservative (speckled top) tube.
Stability Criteria
Room Temperature:
24 hours
Refrigerated:
7 days
Frozen:
30 days
Clinical Significance
The 7-Aminoclonazepam test with quantitative results, conducted using liquid chromatography-tandem mass spectrometry (LC/MS-MS), holds specific clinical significance and diagnostic utility in the field of toxicology and medication monitoring.
7-Aminoclonazepam is an active metabolite of the medication clonazepam, which belongs to the class of benzodiazepines. Benzodiazepines are commonly prescribed for the treatment of anxiety disorders, insomnia, seizures, and other conditions. The presence of 7-Aminoclonazepam in a patient's urine or blood sample indicates recent use or exposure to clonazepam.
LC/MS-MS is a highly sensitive and specific analytical technique utilized for measuring substances in biological samples. It combines liquid chromatography, which separates the components of a sample, with tandem mass spectrometry, which identifies and quantifies the separated components based on their molecular characteristics. LC/MS-MS provides accurate and precise measurements of 7-Aminoclonazepam levels in biological samples.
The 7-Aminoclonazepam test with LC/MS-MS has specific clinical significance and diagnostic applications:
1. Medication Monitoring: The test aids in monitoring patient compliance and therapeutic drug levels when clonazepam is prescribed. It enables healthcare providers to assess whether patients are taking their prescribed medication as directed and whether they have therapeutic levels of clonazepam in their system.
2. Toxicology and Overdose Assessment: In cases of suspected clonazepam overdose or toxicity, the 7-Aminoclonazepam test can confirm exposure to the drug. It assists healthcare professionals in evaluating the extent of overdose, guiding treatment decisions, and monitoring the clearance of clonazepam from the patient's system.
3. Differentiation of Clonazepam from Other Benzodiazepines: Since 7-Aminoclonazepam is specific to clonazepam use, the test helps distinguish clonazepam from other benzodiazepines. This differentiation is crucial when attempting to identify the specific benzodiazepine responsible for a patient's drug-related symptoms or overdose.
4. Forensic and Legal Purposes: The 7-Aminoclonazepam test may be employed in legal and forensic contexts, such as cases involving impaired driving, workplace accidents, or criminal investigations. It provides objective evidence of recent clonazepam use, which can aid in determining legal responsibility or establishing patterns of drug abuse.
In summary, the 7-Aminoclonazepam test with quantitative results using LC/MS-MS holds clinical significance in the areas of toxicology and medication monitoring. It assists in medication compliance monitoring, evaluates overdose or toxicity, differentiates clonazepam from other benzodiazepines, and supports forensic and legal investigations. With its high sensitivity and specificity, this test plays a vital role in assessing clonazepam use, guiding treatment decisions, and providing valuable information to healthcare providers and legal professionals.
CPT Code(s):
80346
Turnaround Time:
24 - 72 hours
Specimen Requirements
Preferred Specimen:
Urine
Minimum Volume:
5.0 mL
Transport Container:
Yellow Top Tube or Sterile Cup
Transport Temperature:
Room Temperature
Collection Instructions:
Collect urine in plastic container and transfer to plain yellow top tube (without preservative).
Rejection Criteria:
Specimen received outside stability requirements; Excessive blood, particulates, viscosity present. Preservative (speckled top) tube.
Stability Criteria
Room Temperature:
24 hours
Refrigerated:
7 days
Frozen:
30 days
Clinical Significance
The 7-Aminoclonazepam test with quantitative results, conducted using liquid chromatography-tandem mass spectrometry (LC/MS-MS), holds specific clinical significance and diagnostic utility in the field of toxicology and medication monitoring.
7-Aminoclonazepam is an active metabolite of the medication clonazepam, which belongs to the class of benzodiazepines. Benzodiazepines are commonly prescribed for the treatment of anxiety disorders, insomnia, seizures, and other conditions. The presence of 7-Aminoclonazepam in a patient's urine or blood sample indicates recent use or exposure to clonazepam.
LC/MS-MS is a highly sensitive and specific analytical technique utilized for measuring substances in biological samples. It combines liquid chromatography, which separates the components of a sample, with tandem mass spectrometry, which identifies and quantifies the separated components based on their molecular characteristics. LC/MS-MS provides accurate and precise measurements of 7-Aminoclonazepam levels in biological samples.
The 7-Aminoclonazepam test with LC/MS-MS has specific clinical significance and diagnostic applications:
1. Medication Monitoring: The test aids in monitoring patient compliance and therapeutic drug levels when clonazepam is prescribed. It enables healthcare providers to assess whether patients are taking their prescribed medication as directed and whether they have therapeutic levels of clonazepam in their system.
2. Toxicology and Overdose Assessment: In cases of suspected clonazepam overdose or toxicity, the 7-Aminoclonazepam test can confirm exposure to the drug. It assists healthcare professionals in evaluating the extent of overdose, guiding treatment decisions, and monitoring the clearance of clonazepam from the patient's system.
3. Differentiation of Clonazepam from Other Benzodiazepines: Since 7-Aminoclonazepam is specific to clonazepam use, the test helps distinguish clonazepam from other benzodiazepines. This differentiation is crucial when attempting to identify the specific benzodiazepine responsible for a patient's drug-related symptoms or overdose.
4. Forensic and Legal Purposes: The 7-Aminoclonazepam test may be employed in legal and forensic contexts, such as cases involving impaired driving, workplace accidents, or criminal investigations. It provides objective evidence of recent clonazepam use, which can aid in determining legal responsibility or establishing patterns of drug abuse.
In summary, the 7-Aminoclonazepam test with quantitative results using LC/MS-MS holds clinical significance in the areas of toxicology and medication monitoring. It assists in medication compliance monitoring, evaluates overdose or toxicity, differentiates clonazepam from other benzodiazepines, and supports forensic and legal investigations. With its high sensitivity and specificity, this test plays a vital role in assessing clonazepam use, guiding treatment decisions, and providing valuable information to healthcare providers and legal professionals.
CPT Code(s):
80346
Turnaround Time:
24 - 72 hours
Specimen Requirements
Preferred Specimen:
Urine
Minimum Volume:
5.0 mL
Transport Container:
Yellow Top Tube or Sterile Cup
Transport Temperature:
Room Temperature
Collection Instructions:
Collect urine in plastic container and transfer to plain yellow top tube (without preservative).
Rejection Criteria:
Specimen received outside stability requirements; Excessive blood, particulates, viscosity present. Preservative (speckled top) tube.
Stability Criteria
Room Temperature:
24 hours
Refrigerated:
7 days
Frozen:
30 days
Clinical Significance
The 7-Aminoclonazepam test with quantitative results, conducted using liquid chromatography-tandem mass spectrometry (LC/MS-MS), holds specific clinical significance and diagnostic utility in the field of toxicology and medication monitoring.
7-Aminoclonazepam is an active metabolite of the medication clonazepam, which belongs to the class of benzodiazepines. Benzodiazepines are commonly prescribed for the treatment of anxiety disorders, insomnia, seizures, and other conditions. The presence of 7-Aminoclonazepam in a patient's urine or blood sample indicates recent use or exposure to clonazepam.
LC/MS-MS is a highly sensitive and specific analytical technique utilized for measuring substances in biological samples. It combines liquid chromatography, which separates the components of a sample, with tandem mass spectrometry, which identifies and quantifies the separated components based on their molecular characteristics. LC/MS-MS provides accurate and precise measurements of 7-Aminoclonazepam levels in biological samples.
The 7-Aminoclonazepam test with LC/MS-MS has specific clinical significance and diagnostic applications:
1. Medication Monitoring: The test aids in monitoring patient compliance and therapeutic drug levels when clonazepam is prescribed. It enables healthcare providers to assess whether patients are taking their prescribed medication as directed and whether they have therapeutic levels of clonazepam in their system.
2. Toxicology and Overdose Assessment: In cases of suspected clonazepam overdose or toxicity, the 7-Aminoclonazepam test can confirm exposure to the drug. It assists healthcare professionals in evaluating the extent of overdose, guiding treatment decisions, and monitoring the clearance of clonazepam from the patient's system.
3. Differentiation of Clonazepam from Other Benzodiazepines: Since 7-Aminoclonazepam is specific to clonazepam use, the test helps distinguish clonazepam from other benzodiazepines. This differentiation is crucial when attempting to identify the specific benzodiazepine responsible for a patient's drug-related symptoms or overdose.
4. Forensic and Legal Purposes: The 7-Aminoclonazepam test may be employed in legal and forensic contexts, such as cases involving impaired driving, workplace accidents, or criminal investigations. It provides objective evidence of recent clonazepam use, which can aid in determining legal responsibility or establishing patterns of drug abuse.
In summary, the 7-Aminoclonazepam test with quantitative results using LC/MS-MS holds clinical significance in the areas of toxicology and medication monitoring. It assists in medication compliance monitoring, evaluates overdose or toxicity, differentiates clonazepam from other benzodiazepines, and supports forensic and legal investigations. With its high sensitivity and specificity, this test plays a vital role in assessing clonazepam use, guiding treatment decisions, and providing valuable information to healthcare providers and legal professionals.