Anti-Mullerian Hormone (AMH)
CPT Code(s):
82397
Turnaround Time:
24 - 48 hours
Specimen Requirements
Preferred Specimen:
Serum
Minimum Volume:
1.0 mL
Transport Container:
Serum Separator Tube (SST) or Red Top Tube
Transport Temperature:
Room Temperature
Collection Instructions:
Transfer specimen to a plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Rejection Criteria:
Citrate, Fluoride,Sodium Heparin, or EDTA plasma specimen; gross hemolysis; lipemia; improper labeling
Stability Criteria
Room Temperature:
3 days
Refrigerated:
5 days
Frozen:
30 days
Clinical Significance
The Anti-Mullerian Hormone (AMH) test holds specific clinical significance and diagnostic use in the field of reproductive medicine and fertility assessment. This test measures the level of AMH in a patient's blood, providing valuable information about ovarian reserve and reproductive potential.
The clinical significance and diagnostic use of AMH include:
1. Assessment of Ovarian Reserve: AMH is produced by the ovarian follicles, and its level in the blood reflects the quantity and quality of a woman's remaining eggs. AMH is used to assess ovarian reserve, which refers to the number of eggs available for fertilization. Low AMH levels may indicate diminished ovarian reserve, suggesting reduced fertility potential or an increased likelihood of age-related infertility.
2. Prediction of Response to Ovarian Stimulation: In assisted reproductive technology (ART) procedures such as in vitro fertilization (IVF), AMH is used to predict a woman's response to ovarian stimulation medications. Higher AMH levels often correlate with a higher number of retrieved eggs during IVF, while low AMH levels may suggest a decreased response to ovarian stimulation. This information helps guide treatment planning and medication dosage adjustments to optimize the chances of successful IVF outcomes.
3. Assessment of Polycystic Ovary Syndrome (PCOS): AMH levels are often elevated in women with polycystic ovary syndrome, a common hormonal disorder that can affect fertility. AMH aids in the diagnosis and evaluation of PCOS, contributing to a comprehensive assessment of the condition and assisting in the development of personalized treatment strategies.
4. Prediction of Menopause Timing: AMH levels decline as women approach menopause, and AMH can provide an indication of the timing of menopause. Very low AMH levels may suggest that menopause is approaching or that a woman is already in perimenopause. This information can be helpful for family planning decisions and counseling women on their reproductive options.
5. Evaluation of Ovarian Tumors: AMH is also used as a tumor marker in certain ovarian tumors, such as granulosa cell tumors. Elevated AMH levels may indicate the presence of these tumors, assisting in their diagnosis and monitoring.
In summary, AMH has specific clinical significance and diagnostic uses in assessing ovarian reserve, predicting response to ovarian stimulation, evaluating polycystic ovary syndrome, predicting menopause timing, and aiding in the diagnosis of certain ovarian tumors. By measuring AMH levels, healthcare providers gain valuable insights into a woman's fertility potential, assisting in fertility treatment planning, counseling on reproductive options, and the diagnosis of related conditions.