High-density Lipoprotein (HDL)
CPT Code(s):
83718
Turnaround Time:
4 hours
Specimen Requirements
Preferred Specimen:
Serum
Minimum Volume:
1.0 mL
Transport Container:
Serum Separator Tube (SST) or Red Top Tube
Transport Temperature:
Room Temperature
Collection Instructions:
Allow blood to clot completely prior to centrifugation. Separate serum from cells within 45 minutes of collection.
Rejection Criteria:
Citrate, Fluoride,Sodium Heparin, or EDTA plasma specimen; gross hemolysis; lipemia; improper labeling
Stability Criteria
Room Temperature:
8 hours
Refrigerated:
7 days
Frozen:
90 days
Clinical Significance
The HDL (High-Density Lipoprotein), Direct test holds specific clinical significance and diagnostic use in assessing the levels of HDL cholesterol in the blood. HDL cholesterol is often referred to as "good" cholesterol due to its beneficial effects on cardiovascular health.
The specific clinical significance and diagnostic use of the HDL, Direct test include:
1. Cardiovascular Disease Risk Assessment: The HDL, Direct test is used to evaluate an individual's risk of developing cardiovascular diseases, particularly coronary artery disease. High levels of HDL cholesterol have been associated with a lower risk of heart disease, while low levels have been linked to an increased risk. The test provides valuable information about an individual's HDL cholesterol levels, which can help assess their cardiovascular health and guide appropriate interventions.
2. Lipid Profile Evaluation: The HDL, Direct test is part of a comprehensive lipid profile, which includes other cholesterol markers such as total cholesterol, LDL cholesterol, and triglycerides. By measuring HDL cholesterol levels, the test provides important information for assessing the overall lipid profile and determining an individual's cardiovascular risk profile.
3. Treatment Monitoring: The HDL, Direct test is used to monitor the effectiveness of lifestyle modifications and medications aimed at improving HDL cholesterol levels. For individuals with low HDL cholesterol, lifestyle changes such as regular physical activity, weight management, smoking cessation, and a heart-healthy diet may be recommended. In some cases, medications such as statins or other lipid-lowering drugs may be prescribed. The test helps evaluate the response to these interventions and guide further treatment decisions.
4. Evaluation of Metabolic Disorders: Abnormal HDL cholesterol levels can be associated with various metabolic disorders, including diabetes, metabolic syndrome, and obesity. The HDL, Direct test aids in the assessment and management of these conditions by providing information about HDL cholesterol levels and contributing to a comprehensive metabolic evaluation.
5. Individualized Treatment Planning: HDL cholesterol levels, as assessed by the HDL, Direct test, can influence treatment decisions and the selection of appropriate interventions. Based on an individual's HDL cholesterol level and overall cardiovascular risk profile, healthcare providers can tailor treatment plans to target specific goals for HDL cholesterol improvement and overall cardiovascular health.
It is important to note that HDL cholesterol levels should be interpreted in the context of other lipid parameters and overall cardiovascular risk factors. Additionally, optimal HDL cholesterol levels may vary depending on an individual's specific medical history, age, sex, and other individual risk factors.
In summary, the HDL, Direct test has specific clinical significance in assessing cardiovascular disease risk, evaluating lipid profiles, monitoring treatment response, evaluating metabolic disorders, and guiding individualized treatment planning. By measuring HDL cholesterol levels in the blood, this test provides valuable information for clinical decision-making, optimizing patient care, and improving cardiovascular health outcomes.