EDDP, Confirmation
CPT Code(s):
80358
Turnaround Time:
24 - 72 hours
Specimen Requirements
Preferred Specimen:
Urine
Minimum Volume:
1.0 mL
Transport Container:
Yellow Top Tube or Sterile Cup
Transport Temperature:
Room Temperature
Collection Instructions:
Collect urine in plastic container and transfer to plain yellow top tube (without preservative).
Rejection Criteria:
Specimen received outside stability requirements; Excessive blood, particulates, viscosity present
Stability Criteria
Room Temperature:
24 hours
Refrigerated:
7 days
Frozen:
30 days
Clinical Significance
The EDDP (Ethylglucuronide) test with quantitative results using liquid chromatography-tandem mass spectrometry (LC/MS-MS) holds specific clinical significance and diagnostic use in the field of toxicology and substance abuse monitoring. EDDP is a metabolite of the drug methadone and is used as a marker to assess methadone use and adherence to methadone maintenance treatment.
The clinical significance and diagnostic use of EDDP with quantitative results include:
1. Methadone Monitoring: EDDP is specifically used to monitor methadone therapy and assess patient compliance with methadone treatment programs. Methadone is commonly prescribed for opioid addiction treatment, and measuring EDDP levels provides an objective marker of methadone use. Quantitative results help healthcare providers determine if patients are consistently taking their prescribed methadone dose as part of their treatment plan.
2. Detection of Methadone Misuse or Diversion: EDDP aids in detecting the misuse or diversion of methadone. By quantifying EDDP levels in a patient's biological sample, such as urine or blood, healthcare providers can identify individuals who are not using methadone as prescribed or may be selling or sharing their medication. Monitoring EDDP levels helps ensure the appropriate use of methadone and enhances patient safety.
3. Methadone Dose Optimization: Quantitative measurement of EDDP levels allows healthcare providers to assess the adequacy of methadone dosing. Methadone treatment requires individualized dose adjustments to achieve optimal therapeutic outcomes. Monitoring EDDP levels provides valuable information to guide methadone dose optimization, ensuring that patients receive an appropriate dose that effectively manages their opioid addiction.
4. Confirmation of Methadone Use: EDDP with quantitative results using LC/MS-MS provides confirmation of methadone use when compared to qualitative or screening tests. LC/MS-MS offers high specificity and sensitivity, allowing for accurate quantification of EDDP levels. This confirmation is especially important in situations where accurate measurement of methadone metabolites is required, such as in legal or forensic settings.
In summary, EDDP with quantitative results using LC/MS-MS has specific clinical significance in monitoring methadone therapy, detecting methadone misuse or diversion, optimizing methadone dosing, and confirming methadone use. By measuring EDDP levels, this test provides valuable information for clinical decision-making, substance abuse treatment, patient monitoring, and legal proceedings related to methadone use.