Fentanyl, Confirmation
CPT Code(s):
80354
Turnaround Time:
24 - 72 hours
Specimen Requirements
Preferred Specimen:
Urine
Minimum Volume:
1.0 mL
Transport Container:
Yellow Top Tube or Sterile Cup
Transport Temperature:
Room Temperature
Collection Instructions:
Collect urine in plastic container and transfer to plain yellow top tube (without preservative).
Rejection Criteria:
Specimen received outside stability requirements; Excessive blood, particulates, viscosity present
Stability Criteria
Room Temperature:
24 hours
Refrigerated:
7 days
Frozen:
30 days
Clinical Significance
Fentanyl with quantitative results using liquid chromatography-tandem mass spectrometry (LC/MS-MS) holds specific clinical significance and diagnostic use in the field of toxicology and drug monitoring. Fentanyl is a potent synthetic opioid used for pain management, but its misuse and abuse pose significant health risks.
The clinical significance and diagnostic use of Fentanyl with quantitative results include:
1. Detection of Fentanyl Use: The test helps detect the presence of fentanyl in a patient's biological samples, such as urine or blood. It provides objective evidence of recent fentanyl use and aids in diagnosing fentanyl abuse, assessing patient compliance with prescribed fentanyl therapy, and identifying cases of illicit fentanyl use.
2. Monitoring Medication Adherence: The test is used to monitor patients receiving fentanyl therapy for chronic pain. Quantitative measurement of fentanyl levels helps healthcare providers ensure medication adherence and assess if the prescribed dose is within the therapeutic range. Monitoring fentanyl levels can also assist in optimizing pain management and adjusting medication dosage as necessary.
3. Overdose Management: Fentanyl with quantitative results is valuable in the management of fentanyl overdose cases. By quantifying fentanyl levels in a patient's system, healthcare providers can determine the extent of fentanyl exposure and guide appropriate treatment interventions, such as naloxone administration, respiratory support, and overall patient management.
4. Forensic and Legal Applications: Fentanyl is relevant in forensic and legal contexts, especially in cases involving drug-related offenses, impaired driving, or fatalities associated with fentanyl use. Quantitative results obtained through LC/MS-MS can provide accurate measurements of fentanyl levels, supporting legal investigations, and facilitating informed decision-making in legal proceedings.
5. Pharmacokinetic Studies: Quantitative measurement of fentanyl levels using LC/MS-MS supports pharmacokinetic studies, allowing researchers to better understand fentanyl metabolism, clearance, and drug-drug interactions. These studies contribute to optimizing dosing strategies, identifying potential drug interactions, and improving patient safety and therapeutic outcomes.
It is important to note that Fentanyl with quantitative results using LC/MS-MS provides accurate and precise measurement of fentanyl levels compared to qualitative or screening tests. Quantitative results allow for a better understanding of the extent of fentanyl exposure, aiding in diagnosis, treatment management, and forensic investigations.
In summary, Fentanyl with quantitative results using LC/MS-MS has specific clinical significance in detecting fentanyl use, monitoring medication adherence, managing overdose cases, supporting forensic and legal investigations, and contributing to pharmacokinetic studies. By measuring fentanyl levels in a patient's biological samples, this test provides valuable information for clinical decision-making, substance abuse monitoring, forensic analysis, and optimizing patient care outcomes related to fentanyl use.