Hydromorphone, Confirmation

CPT Code(s):
80361

Turnaround Time:
24 - 72 hours

Specimen Requirements

Preferred Specimen:
Urine

Minimum Volume:
1.0 mL

Transport Container:
Yellow Top Tube or Sterile Cup

Transport Temperature:
Room Temperature

Collection Instructions:
Collect urine in plastic container and transfer to plain yellow top tube (without preservative).

Rejection Criteria:
Specimen received outside stability requirements; Excessive blood, particulates, viscosity present

Stability Criteria

Room Temperature:
24 hours

Refrigerated:
7 days

Frozen:
30 days

Clinical Significance

Hydromorphone with quantitative results using liquid chromatography-tandem mass spectrometry (LC/MS-MS) holds specific clinical significance and diagnostic use in the detection and quantification of hydromorphone, a potent opioid analgesic, in a patient's biological sample.

The specific clinical significance and diagnostic use of Hydromorphone with quantitative results include:

1. Medication Monitoring: The test is used to monitor hydromorphone levels in patients receiving prescribed opioid therapy. It helps ensure adherence to the prescribed dosage and assesses the effectiveness of the medication in managing pain.

2. Abuse and Misuse Detection: Hydromorphone has a high potential for abuse and misuse. The test helps identify patients who may be misusing or diverting their medication, providing valuable information for healthcare providers to intervene and adjust treatment plans accordingly.

3. Dose Optimization: Quantitative results from Hydromorphone can guide healthcare providers in optimizing the dosage of hydromorphone or considering alternative pain management strategies. It ensures effective pain relief while minimizing the risk of adverse effects or misuse.

4. Toxicity Assessment: Hydromorphone can cause respiratory depression, sedation, and other adverse effects, particularly when taken in excessive amounts. The test aids in assessing hydromorphone levels in cases of suspected overdose or toxicity, guiding appropriate medical interventions and monitoring response to treatment.

5. Forensic and Legal Purposes: Hydromorphone with quantitative results may be used in legal or forensic settings to provide objective evidence of hydromorphone use or misuse. It can be valuable in cases involving impaired driving, workplace drug testing, or legal disputes related to opioid use.

Interpretation of the quantitative results of Hydromorphone should consider the patient's clinical condition, medical history, and prescribed medication regimen. The test should be used in conjunction with other clinical information to make informed decisions regarding pain management and patient care.

In summary, Hydromorphone with quantitative results using LC/MS-MS is specifically used for medication monitoring, detecting abuse or misuse, optimizing dosages, assessing toxicity, and providing objective evidence in forensic or legal contexts. It assists healthcare providers in optimizing pain management while promoting patient safety and reducing the risks associated with hydromorphone use.