Insulin, 2hr, 75g

CPT Code(s):
83525 (2)

Turnaround Time:
8 hours

Specimen Requirements

Preferred Specimen:
Serum

Minimum Volume:
1.0 mL

Transport Container:
Serum Separator Tube (SST) or Red Top Tube

Transport Temperature:
Room Temperature

Collection Instructions:
Collect first fasting specimen before adminstering 75 gram Glucola. Draw second specimen 2 hours post Glucola. Allow blood to clot completely prior to centrifugation. Separate serum from cells within 45 minutes of collection.

Rejection Criteria:
Gross hemolysis; lipemia; improper labeling

Stability Criteria

Room Temperature:
2 hours

Refrigerated:
24 hours

Frozen:
30 days

Clinical Significance

The Insulin, 2 hour PP 75g Glucola holds specific clinical significance and diagnostic use in assessing insulin levels after a glucose challenge, particularly in the context of evaluating glucose metabolism and insulin response in patients.

The specific clinical significance and diagnostic use of the Insulin, 2 hour PP 75g Glucola include:

1. Diabetes Diagnosis: The test is used in the evaluation of impaired glucose tolerance and the diagnosis of diabetes. After consuming a glucose solution (75g), insulin levels are measured 2 hours later to assess the body's response to the glucose load. Abnormal insulin levels can indicate impaired insulin secretion or insulin resistance, both of which are common features in diabetes.

2. Glucose Metabolism Assessment: The Insulin, 2 hour PP 75g Glucola provides valuable information about the body's ability to handle glucose. It helps identify individuals with impaired glucose regulation, such as impaired glucose tolerance or prediabetes, who are at increased risk of developing type 2 diabetes.

3. Treatment Monitoring: For patients already diagnosed with diabetes, the test aids in monitoring the effectiveness of glucose-lowering treatments, such as lifestyle modifications or medication. Measuring insulin levels 2 hours after a glucose challenge can assess the response to therapy and guide treatment adjustments.

4. Research and Clinical Trials: The Insulin, 2 hour PP 75g Glucola is frequently used in research studies and clinical trials focused on glucose metabolism, insulin resistance, and diabetes management. It provides valuable data for evaluating the effects of interventions or therapies aimed at improving insulin sensitivity or glucose regulation.

Interpretation of the Insulin, 2 hour PP 75g Glucola results should consider the patient's clinical context, including fasting insulin levels and concurrent glucose measurements. The test is typically performed in conjunction with other glucose-related parameters, such as fasting plasma glucose or glycated hemoglobin (HbA1c), to obtain a comprehensive assessment of glucose metabolism.

In summary, the Insulin, 2 hour PP 75g Glucola is specifically used for diabetes diagnosis, assessing glucose metabolism, monitoring treatment efficacy, and supporting research and clinical trials related to diabetes and insulin resistance. It helps healthcare providers evaluate insulin response to a glucose challenge and make informed decisions regarding patient care and management of diabetes and related conditions.