Iron and Total Iron Binding Capacity
CPT Code(s):
83550, 83540
Turnaround Time:
4 hours
Specimen Requirements
Preferred Specimen:
Serum
Minimum Volume:
1.0 mL
Transport Container:
Serum Separator Tube (SST) or Red Top Tube
Transport Temperature:
Room Temperature
Collection Instructions:
Allow blood to clot completely prior to centrifugation. Separate serum from cells within 45 minutes of collection.
Rejection Criteria:
Citrate, Fluoride,Sodium Heparin, or EDTA plasma specimen; gross hemolysis; lipemia; improper labeling
Stability Criteria
Room Temperature:
4 days
Refrigerated:
7 days
Frozen:
60 days
Clinical Significance
The Iron and Total Iron Binding Capacity (TIBC) test holds specific clinical significance and diagnostic use in assessing iron metabolism and iron-binding capacity in a patient's blood. It provides valuable information about iron levels and the body's ability to transport and store iron, aiding in the evaluation of various iron-related disorders.
The specific clinical significance and diagnostic use of Iron and TIBC include:
1. Diagnosis of Iron Deficiency Anemia: The test helps diagnose iron deficiency anemia by evaluating both iron levels and TIBC. Low iron levels and high TIBC levels are characteristic of iron deficiency, indicating insufficient iron stores and increased capacity for binding iron.
2. Assessment of Iron Overload Disorders: Iron and TIBC aids in assessing iron overload disorders, such as hereditary hemochromatosis or secondary iron overload due to repeated blood transfusions. Abnormal iron and TIBC levels can help identify excessive iron accumulation or impaired iron transport.
3. Monitoring Iron Replacement Therapy: For patients undergoing iron supplementation or treatment for iron deficiency, Iron and TIBC helps monitor the response to therapy. Regular monitoring of iron levels and TIBC assists healthcare providers in adjusting iron supplementation dosage and duration.
4. Evaluation of Anemia: The test provides additional information in the evaluation of anemia, as both iron and TIBC contribute to understanding iron availability and utilization in red blood cell production. It helps differentiate various types of anemia, such as iron deficiency anemia, anemia of chronic disease, or sideroblastic anemia.
5. Assessment of Iron Metabolism: Iron and TIBC aids in assessing overall iron metabolism and transport capacity. It provides insights into the body's ability to absorb, transport, and store iron, helping to identify underlying abnormalities in iron metabolism.
Interpretation of Iron and TIBC results involves evaluating the relationship between iron and TIBC levels, as well as other iron-related parameters such as ferritin and transferrin saturation. Additional tests, such as transferrin or transferrin saturation, may be required for a comprehensive evaluation of iron metabolism.
In summary, Iron and TIBC is specifically used for diagnosing iron deficiency anemia, assessing iron overload disorders, monitoring iron replacement therapy, evaluating anemia, and assessing iron metabolism. It plays a critical role in the evaluation and management of iron-related disorders, helping healthcare providers make informed decisions regarding patient care and treatment strategies. Close collaboration between healthcare providers and patients is crucial to interpret the test results accurately and implement appropriate treatment plans.