MDPV, Confirmation

CPT Code(s):
80371

Turnaround Time:
24 - 72 hours

Specimen Requirements

Preferred Specimen:
Urine

Minimum Volume:
1.0 mL

Transport Container:
Yellow Top Tube or Sterile Cup

Transport Temperature:
Room Temperature

Collection Instructions:
Collect urine in plastic container and transfer to plain yellow top tube (without preservative).

Rejection Criteria:
Specimen received outside stability requirements; Excessive blood, particulates, viscosity present

Stability Criteria

Room Temperature:
24 hours

Refrigerated:
7 days

Frozen:
30 days

Clinical Significance

The MDPV (methylenedioxypyrovalerone) test with quantitative results using liquid chromatography-tandem mass spectrometry (LC/MS-MS) holds specific clinical significance and diagnostic use in measuring the concentration of MDPV or its metabolites in a patient's biological sample. MDPV is a synthetic stimulant drug that belongs to the cathinone class, commonly known as a "bath salt" or "designer drug."

The specific clinical significance and diagnostic use of MDPV include:

1. Toxicology Screening: MDPV is employed in toxicology screening to confirm the presence and quantify the amount of MDPV or its metabolites in a patient's system. This is particularly useful in emergency situations where MDPV intoxication is suspected. Accurate and quantitative results contribute to the diagnosis and appropriate medical management of MDPV-related toxicity.

2. Forensic Investigations: MDPV plays a crucial role in forensic investigations and legal proceedings. It provides objective evidence of MDPV use or exposure, assisting law enforcement agencies, forensic laboratories, and legal professionals in investigating drug-related incidents, conducting drug testing, and providing evidence in legal cases involving MDPV.

3. Research and Epidemiology: Quantitative MDPV testing using LC/MS-MS is valuable in research and epidemiological studies aimed at understanding patterns of MDPV use, assessing drug trends, and evaluating the impact of MDPV on public health. Such data can inform policy decisions, preventive strategies, and public health interventions related to MDPV use.

Interpretation of the quantitative results of MDPV should consider the patient's clinical context, drug history, and the specific MDPV metabolites detected. It is important to note that MDPV is a designer drug, and its chemical structure may vary across different formulations, making comprehensive testing essential to detect its metabolites accurately.

In summary, MDPV with quantitative results using LC/MS-MS is specifically used for toxicology screening, forensic investigations, and research purposes. It provides valuable information about the presence and concentration of MDPV or its metabolites, aiding healthcare providers, forensic experts, and researchers in various aspects related to MDPV use and exposure. Close collaboration between laboratory professionals, healthcare providers, and other relevant stakeholders is crucial for accurate interpretation of the test results and appropriate patient management.