Morphine, Confirmation
CPT Code(s):
80361
Turnaround Time:
24 - 72 hours
Specimen Requirements
Preferred Specimen:
Urine
Minimum Volume:
1.0 mL
Transport Container:
Yellow Top Tube or Sterile Cup
Transport Temperature:
Room Temperature
Collection Instructions:
Collect urine in plastic container and transfer to plain yellow top tube (without preservative).
Rejection Criteria:
Specimen received outside stability requirements; Excessive blood, particulates, viscosity present
Stability Criteria
Room Temperature:
24 hours
Refrigerated:
7 days
Frozen:
30 days
Clinical Significance
Morphine with quantitative results using liquid chromatography-tandem mass spectrometry (LC/MS-MS) holds specific clinical significance and diagnostic use in measuring the concentration of morphine in a patient's biological sample. Morphine is a potent opioid analgesic commonly used for pain management.
The specific clinical significance and diagnostic use of Morphine include:
1. Toxicology Screening: Morphine with quantitative results is used for toxicology screening to confirm the presence and quantify the amount of morphine in a patient's sample. It helps in identifying morphine use, monitoring for drug misuse or abuse, and assessing potential overdose situations.
2. Pain Management: Quantitative results from Morphine assist healthcare providers in monitoring patients who are prescribed morphine-based medications for pain management. It helps ensure appropriate dosing, optimize therapeutic outcomes, and detect potential medication non-compliance.
3. Forensic Investigations: Morphine plays a crucial role in forensic investigations and legal proceedings. It provides objective evidence of morphine use or exposure, aiding law enforcement agencies, forensic laboratories, and legal professionals in investigating drug-related incidents, conducting drug testing, and providing evidence in legal cases involving morphine.
4. Clinical Pharmacokinetics: Morphine with quantitative results is used in pharmacokinetic studies to assess the metabolism and elimination of morphine in patients. It helps determine drug clearance rates, drug interactions, and individual variations in drug metabolism, which can guide personalized dosing strategies.
Interpretation of the quantitative results of Morphine should consider the patient's clinical context, drug history, and the specific morphine concentrations detected. Monitoring morphine levels helps ensure medication adherence, evaluate treatment effectiveness, and detect potential risks associated with its use.
It's important to note that Morphine with quantitative results using LC/MS-MS provides accurate and reliable quantification of morphine in a patient's sample. It offers enhanced sensitivity and specificity compared to other screening methods, enabling precise measurements in a wide dynamic range.
In summary, Morphine with quantitative results using LC/MS-MS is specifically used for toxicology screening, pain management, forensic investigations, and clinical pharmacokinetics. It provides valuable information about the presence and concentration of morphine, aiding healthcare providers, forensic experts, researchers, and legal professionals in various aspects related to morphine use and exposure. Collaboration between laboratory professionals, healthcare providers, researchers, and other relevant stakeholders is essential for accurate interpretation of the test results and appropriate patient care.