Nordiazepam, Confirmation
CPT Code(s):
80346
Turnaround Time:
24 - 72 hours
Specimen Requirements
Preferred Specimen:
Urine
Minimum Volume:
1.0 mL
Transport Container:
Yellow Top Tube or Sterile Cup
Transport Temperature:
Room Temperature
Collection Instructions:
Collect urine in plastic container and transfer to plain yellow top tube (without preservative).
Rejection Criteria:
Specimen received outside stability requirements; Excessive blood, particulates, viscosity present
Stability Criteria
Room Temperature:
24 hours
Refrigerated:
7 days
Frozen:
30 days
Clinical Significance
Nordiazepam with quantitative results using liquid chromatography-tandem mass spectrometry (LC/MS-MS) has specific clinical significance and diagnostic use in measuring the concentration of nordiazepam in a patient's biological sample. Nordiazepam is a metabolite of diazepam, a benzodiazepine medication used to treat anxiety, insomnia, and seizures.
The specific clinical significance and diagnostic use of Nordiazepam include:
1. Medication Adherence: Nordiazepam helps healthcare providers monitor patient compliance with diazepam therapy. By measuring the concentration of nordiazepam, a major metabolite of diazepam, in a patient's sample, it provides objective evidence of medication adherence and helps ensure that the patient is taking the prescribed medication.
2. Treatment Optimization: Quantitative results from Nordiazepam assist healthcare providers in optimizing diazepam therapy for patients. By monitoring the concentration of nordiazepam, healthcare providers can assess the effectiveness of the current dosage and make adjustments if necessary to achieve optimal treatment outcomes.
3. Assessing Metabolism and Pharmacokinetics: Nordiazepam using LC/MS-MS aids in assessing the metabolism and pharmacokinetics of diazepam in individual patients. It provides valuable information on the rate of drug metabolism, individual variations in drug clearance, and potential drug interactions. This information can guide personalized dosing strategies and help avoid potential adverse effects or inadequate therapeutic response.
4. Forensic Investigations: Nordiazepam is also used in forensic investigations and legal proceedings, providing objective evidence of diazepam use or exposure. It can be valuable in cases involving medication compliance, forensic toxicology, or legal disputes related to diazepam therapy.
Interpretation of the quantitative results of Nordiazepam should consider the patient's clinical context, treatment history, and the specific nordiazepam concentrations detected. Monitoring nordiazepam levels helps ensure medication adherence, evaluate treatment effectiveness, and detect potential risks associated with diazepam use.
It's important to note that Nordiazepam with quantitative results using LC/MS-MS provides accurate and reliable quantification of nordiazepam in a patient's sample. This method offers enhanced sensitivity and specificity, enabling precise measurements in a wide dynamic range.
In summary, Nordiazepam with quantitative results using LC/MS-MS is specifically used for medication adherence monitoring, treatment optimization, assessment of metabolism and pharmacokinetics, and forensic investigations. It provides valuable information about the concentration of nordiazepam in a patient's sample, aiding healthcare providers, researchers, forensic experts, and legal professionals in various aspects related to diazepam therapy and use. Collaboration between laboratory professionals, healthcare providers, researchers, and other relevant stakeholders is essential for accurate interpretation of the test results and appropriate patient care.