Oxymorphone, Confirmation
CPT Code(s):
80362
Turnaround Time:
24 - 72 hours
Specimen Requirements
Preferred Specimen:
Urine
Minimum Volume:
1.0 mL
Transport Container:
Yellow Top Tube or Sterile Cup
Transport Temperature:
Room Temperature
Collection Instructions:
Collect urine in plastic container and transfer to plain yellow top tube (without preservative).
Rejection Criteria:
Specimen received outside stability requirements; Excessive blood, particulates, viscosity present
Stability Criteria
Room Temperature:
24 hours
Refrigerated:
7 days
Frozen:
30 days
Clinical Significance
Oxymorphone with quantitative results, using liquid chromatography-tandem mass spectrometry (LC/MS-MS), has specific clinical significance and diagnostic use in detecting and measuring the levels of oxymorphone, a potent opioid analgesic, in a patient's system. Oxymorphone is primarily used for the management of moderate to severe pain.
The specific clinical significance and diagnostic use of Oxymorphone include:
1. Therapeutic Drug Monitoring: The test helps healthcare providers monitor the concentration of oxymorphone in a patient's blood or urine to ensure the medication is being taken as prescribed. Therapeutic drug monitoring assists in optimizing the dosage and tailoring treatment to achieve adequate pain relief while minimizing the risk of side effects.
2. Treatment Optimization: Quantitative measurement of oxymorphone levels allows healthcare providers to assess the effectiveness of the medication and make necessary adjustments to the dosage or treatment plan. Monitoring oxymorphone concentrations helps ensure that patients are receiving optimal pain management and can guide decision-making in cases where the current dose is insufficient or associated with adverse effects.
3. Compliance Monitoring: Oxymorphone is used to assess patient compliance with prescribed therapy. By quantifying oxymorphone levels, healthcare providers can determine if patients are taking the medication as directed. Monitoring compliance is particularly important in cases where there are concerns about potential non-adherence or misuse of the medication.
4. Pharmacokinetic Studies: The test is valuable in pharmacokinetic studies, enabling researchers to investigate the absorption, distribution, metabolism, and elimination of oxymorphone in different patient populations or under specific conditions. This information contributes to a better understanding of the drug's pharmacokinetics and aids in dosage adjustment recommendations.
5. Forensic Investigations: Oxymorphone can be used in forensic toxicology to detect and quantify oxymorphone in biological samples, such as blood or urine. This helps establish the presence of the drug in cases related to drug-facilitated crimes, impaired driving, or workplace incidents.
LC/MS-MS provides highly accurate and precise measurement of oxymorphone levels in biological samples, allowing for more reliable clinical interpretation and decision-making.
In summary, Oxymorphone with quantitative results using LC/MS-MS is clinically significant in therapeutic drug monitoring, treatment optimization, compliance monitoring, pharmacokinetic studies, and forensic investigations. Accurate measurement of oxymorphone levels assists healthcare providers in optimizing therapy, assessing patient compliance, and minimizing the risk of adverse effects. Collaborative efforts between healthcare providers and laboratory professionals are crucial in interpreting the test results and providing appropriate patient care.