Rapid Plasma Reagin (RPR), Titer
CPT Code(s):
86593
Turnaround Time:
8 hours
Specimen Requirements
Preferred Specimen:
Serum
Minimum Volume:
1.0 mL
Transport Container:
Serum Separator Tube (SST)
Transport Temperature:
Room Temperature
Collection Instructions:
Allow blood to clot completely prior to centrifugation. Separate serum from cells within 45 minutes of collection.
Rejection Criteria:
Citrate, Fluoride,Sodium Heparin specimen; gross hemolysis; lipemia; improper labeling
Stability Criteria
Room Temperature:
5 days
Refrigerated:
5 days
Frozen:
7 days
Clinical Significance
The Rapid Plasma Reagin (RPR), Titer test is a specific clinical test used in the diagnosis and monitoring of syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum. It is a variation of the standard RPR and provides additional information by measuring the antibody titer.
The clinical significance and diagnostic use of the RPR, Titer test include:
1. Diagnosis of Syphilis: The RPR, Titer test is used as a confirmatory test in the diagnosis of syphilis. It measures the level of antibodies, specifically immunoglobulin M (IgM) and immunoglobulin G (IgG), in the patient's blood. A positive RPR, Titer test result, along with compatible clinical signs and symptoms, confirms the diagnosis of syphilis.
2. Monitoring Disease Activity: The RPR, Titer test is also used to monitor the progression and treatment response in individuals with syphilis. Serial RPR, Titer tests may be performed at regular intervals to assess changes in antibody titers over time. A declining titer indicates successful treatment and resolution of the infection, while an increasing or persistent titer suggests ongoing or recurrent infection.
3. Evaluation of Treatment Efficacy: After initiating treatment for syphilis, the RPR, Titer test is used to monitor the effectiveness of therapy. A decreasing titer over time indicates a positive treatment response. Sustained decline or seroreversion (becoming non-reactive) of the RPR, Titer test is indicative of successful treatment and resolution of the infection.
4. Assessment of Reinfection or Treatment Failure: In cases where there is a rise or persistence of the RPR, Titer test titer after initial treatment, it may indicate reinfection or treatment failure. Further evaluation and management are necessary to determine the appropriate course of action, such as adjusting the treatment regimen or considering additional diagnostic tests.
It is important to note that the RPR, Titer test should be used in conjunction with other diagnostic tests, such as treponemal-specific tests (e.g., Treponema pallidum particle agglutination assay, fluorescent treponemal antibody absorption test), for accurate diagnosis and management of syphilis.
In summary, the Rapid Plasma Reagin (RPR), Titer test is a valuable tool in the diagnosis, monitoring, and evaluation of treatment response in individuals with syphilis. It provides information on the antibody titer, helping clinicians assess disease activity, treatment efficacy, and the need for further intervention. Combined with other diagnostic tests, the RPR, Titer test aids in the comprehensive management of syphilis infection.