Temazepam, Confirmation
CPT Code(s):
80346
Turnaround Time:
24 - 72 hours
Specimen Requirements
Preferred Specimen:
Urine
Minimum Volume:
1.0 mL
Transport Container:
Yellow Top Tube or Sterile Cup
Transport Temperature:
Room Temperature
Collection Instructions:
Collect urine in plastic container and transfer to plain yellow top tube (without preservative).
Rejection Criteria:
Specimen received outside stability requirements; Excessive blood, particulates, viscosity present
Stability Criteria
Room Temperature:
24 hours
Refrigerated:
7 days
Frozen:
30 days
Clinical Significance
Temazepam with quantitative results, using liquid chromatography-tandem mass spectrometry (LC/MS-MS), is a diagnostic tool used to measure the levels of temazepam, a benzodiazepine sedative-hypnotic medication, in a patient's blood or urine. This test has specific clinical significance and diagnostic use in the following ways:
1. Medication Monitoring: Temazepam is prescribed for the treatment of insomnia and other sleep disorders. The quantitative temazepam test helps monitor medication adherence and assess drug levels in the patient's system. It ensures that patients are taking the appropriate dosage and helps healthcare providers adjust treatment plans if necessary.
2. Therapeutic Drug Monitoring: Temazepam has a narrow therapeutic window, meaning there is a fine balance between the desired sedative effects and potential adverse effects. Quantitative testing allows healthcare providers to monitor temazepam levels and ensure they are within the therapeutic range. This information assists in optimizing treatment and minimizing the risk of side effects or inadequate sleep improvement.
3. Detection of Drug Misuse or Abuse: The temazepam test can detect the presence of temazepam in a patient's system, helping identify cases of misuse or abuse. Quantitative results provide information on the level of temazepam in the patient's blood or urine, allowing healthcare providers to assess whether the drug is being used appropriately or if there are signs of excessive use.
4. Assessment of Drug Clearance: Quantitative testing can provide insights into the rate at which temazepam is eliminated from the patient's system. This information is particularly relevant when evaluating drug interactions or considering dosage adjustments in patients with impaired renal or hepatic function.
5. Forensic or Workplace Drug Testing: Temazepam testing may be utilized in forensic or workplace settings to detect the presence of temazepam in individuals subject to drug screening. The quantitative results can provide accurate measurements of temazepam levels, helping determine compliance with drug policies or legal requirements.
It is important to note that the interpretation of temazepam test results should consider other factors such as the patient's medical history, concurrent medications, and clinical presentation. The test should be performed and interpreted by qualified healthcare professionals experienced in toxicology and sleep medicine.
In summary, the temazepam test with quantitative results using LC/MS-MS is a valuable diagnostic tool for medication monitoring, therapeutic drug monitoring, detection of drug misuse or abuse, assessment of drug clearance, and forensic or workplace drug testing. It assists healthcare providers in optimizing treatment, ensuring patient safety, and maintaining compliance with treatment plans and regulatory requirements.