Testosterone, Total
CPT Code(s):
84403
Turnaround Time:
4 hours
Specimen Requirements
Preferred Specimen:
Serum
Minimum Volume:
1.0 mL
Transport Container:
Serum Separator Tube (SST) or Red Top Tube
Transport Temperature:
Room Temperature
Collection Instructions:
Allow blood to clot completely prior to centrifugation. Separate serum from cells within 45 minutes of collection.
Rejection Criteria:
Sodium Citrate plasma; gross hemolysis; lipemia; improper labeling
Stability Criteria
Room Temperature:
24 hours
Refrigerated:
7 days
Frozen:
30 days
Clinical Significance
The Testosterone, Total test is a commonly used diagnostic tool to measure the total concentration of testosterone in a patient's blood. It has specific clinical significance and diagnostic use in the following ways:
1. Evaluation of Hypogonadism: Hypogonadism is a condition characterized by low testosterone levels, which can lead to symptoms such as decreased libido, fatigue, decreased muscle mass, and mood changes. The Testosterone, Total test helps in diagnosing and monitoring hypogonadism by assessing the overall testosterone production in the body.
2. Assessment of Androgen-Related Disorders: Disorders related to androgen deficiency or excess, such as Klinefelter syndrome or adrenal gland disorders, can be evaluated through the measurement of total testosterone levels. Abnormal testosterone levels can help in diagnosing these conditions and guiding appropriate treatment strategies.
3. Monitoring Testosterone Replacement Therapy: Testosterone replacement therapy (TRT) is often prescribed to individuals with low testosterone levels. Monitoring the total testosterone levels helps in assessing the effectiveness of TRT and ensuring that therapeutic levels are achieved and maintained. This information enables healthcare providers to optimize TRT dosages and treatment regimens.
4. Evaluation of Pubertal Development: The Testosterone, Total test is also useful in assessing the timing and progression of pubertal development in both boys and girls. Abnormal testosterone levels can indicate delayed or early puberty, which may require further investigation and intervention.
5. Investigating Fertility Issues: Testosterone plays a crucial role in male fertility. Low levels of testosterone can affect sperm production and quality, leading to fertility issues. Measuring total testosterone levels can provide insight into potential causes of male infertility.
It is important to note that the interpretation of test results should be done in conjunction with the patient's clinical presentation, medical history, and other laboratory findings. Reference ranges may vary depending on the laboratory performing the test, and age-specific reference ranges are often used for pediatric and adolescent patients.
In summary, the Testosterone, Total test is clinically significant and diagnostically useful for evaluating hypogonadism, assessing androgen-related disorders, monitoring testosterone replacement therapy, evaluating pubertal development, and investigating fertility issues. It provides valuable information for healthcare providers in diagnosing and managing patients with testosterone-related conditions, optimizing treatment regimens, and guiding patient care.